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Clinical Chemistry 10: 1050-1053, 1964;
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Clinical Chemistry, Vol 10, 1050-1053, Copyright © 1964 by the American Association for Clinical Chemistry

Clinical Studies on Glucose Metabolism via the Pentose Phosphate Pathway in Human Erythrocytes

Edwin G. Olmstead 1 and John H. Lunseth 1

1 Departments of Medicine and Pathology, Guy and Bertha Ireland Research Laboratory, University of North Dakota School of Medicine, Grand Forks, and Veterans Hospital, Fargo, North Dakota.

Glucose metabolism via the pintos phosphate pathway was studied by measuring accelerated O2 uptake of human erythrocytes in the presence of methylene blue. Erythrocyte 02 uptake was independent of age in 67 normal patients. Erythrocyte 02 uptake was increased in pernicious anemia in relapse and in 5 of 6 jaundiced patients but was normal in pernicious anemia in remission and in 20 cases of malignancies of various types. In the latter cases there was no correlation between erythrocyte 02 uptake and hemoglobin content or reticulocyte count.

Submitted on November 20, 1963
Accepted on December 27, 1963






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Copyright © 1964 by the American Association for Clinical Chemistry.