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Clinical Chemistry 10: 335-345, 1964;
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Clinical Chemistry, Vol 10, 335-345, Copyright © 1964 by the American Association for Clinical Chemistry

Enzyme Activities during Hepatic Injury Caused by Carbon Tetrachloride

Max M. Friedman 1 and Bernard Lapan 1

1 Chemistry Division and the Dr. Milton J. Goodfriend Laboratory, Department of Laboratories, Bronx-Lebanon Hospital Center, Concourse Division, Bronx 57, N. Y.

Rats injected with carbon tetrachloride show markedly elevated plasma glutamic oxalacetic transaminase and plasma fumarase but, at the same time, these enzyme activities do not decrease in the liver.

Three mechanisms are proposed which may account for the increase in plasma enzymes: first, a transfer of the enzyme systems from the necrotized liver cell to the plasma; second, the synthesis of plasma enzymes as the response to hepatic injury; third, disruption of the mitochondrion.

Submitted on April 5, 1963






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Copyright © 1964 by the American Association for Clinical Chemistry.