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Clinical Chemistry 10: 581-588, 1964;
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Clinical Chemistry, Vol 10, 581-588, Copyright © 1964 by the American Association for Clinical Chemistry

Screening Test for Fast Isoniazid Inactivators

L. Eidus 1 and E. J. Hamilton 1

1 Laboratory of Hygiene, Department of National Health and Welfare, Ottawa, Canada.

A screening test is described for assaying fast inactivators of isoniazid (INH) in serum. Trichloracetic acid filtrates are reacted with a trans-cinnamaldehyde reagent to form a colored hydrazone derivative of INH. The metabolic degradation of the drug is discussed as well as interferences. The color is read at 352-354 mµ.

Submitted on March 21, 1963






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Copyright © 1964 by the American Association for Clinical Chemistry.