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Clinical Chemistry 10: 736-740, 1964;
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Clinical Chemistry, Vol 10, 736-740, Copyright © 1964 by the American Association for Clinical Chemistry

Serum Glycoproteins and Seromucoid in Patients with Myocardial Infarction

J. W. Keyser 1 and B. T. Stephens 1

1 Department of Pathology and Bacteriology, The Welsh National School of Medicine, Royal Infirmary, Cardiff, U. K.

Seromucoid and serum total glycoproteins were measured in 7 patients with myocardial infarction. In all cases the highest concentrations of these proteins were reached several days after the concentration of glutamic-oxalacetic transaminase had begun to return to normal. In 2 cases paper electrophoretic analysis of the serum proteins was performed. A rise in the concentration of 1- and 2-globulins occurred after infarction, and PAS staining indicated that the rise in total glycoprotein was largely or entirely accounted for by these two fractions. The concentration of serum albumin fell considerably after infarction, reaching a minimum at about 6 days; - and -globulin concentrations appeared to fall slightly. In general, the presence of C-reactive protein corresponded roughly with the period during which the seromucoid concentration was elevated. It is suggested that the elevation of seromucoid and total glycoproteins represents a nonspecific response to the tissue injury.

Submitted on February 19, 1963






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Copyright © 1964 by the American Association for Clinical Chemistry.