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Clinical Chemistry 12: 690-696, 1966;
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Clinical Chemistry, Vol 12, 690-696, Copyright © 1966 by the American Association for Clinical Chemistry

A Quantitative Procedure for the Determination of Nitrofurantoin in Whole Blood and Plasma

John D. Conklin 1 and Richard D. Hollifield 1

1 Laboratories, The Norwich Pharmacal Co., Norwich, N. Y. 13815.

A rapid, quantitative procedure for the determination of nitrofurantoin in 0.5 ml. of whole blood and plasma is presented. The method has a sensitivity of 2 mg./L., with recoveries of 95-100%. The absorbance-concentration curve is linear to 60 mg./L.

Submitted on March 14, 1966
Accepted on June 20, 1966






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Copyright © 1966 by the American Association for Clinical Chemistry.