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Clinical Chemistry 12: 803-807, 1966;
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Clinical Chemistry, Vol 12, 803-807, Copyright © 1966 by the American Association for Clinical Chemistry

The Interference of Chlorpromazine Metabolites in the Analysis of Urinary Methoxy-Catecholamines

Arnold G. Blumberg 1, Audre M. Heaton 1, and John Vassiliades 1

1 Division of Medical Services, Hillside Hospital, Glen Oaks, N. Y. 11004.

The analysis of urinary methoxy-catecholamines by the method of Pisano (1) could not be applied to the urine of patients who were receiving chlorpromazine. Chlor-promazine and the chlorpromazine metabolites, 7-hydroxychlorpromazine and chlor-promazine sulfoxide, were shown to interfere with the column chromatographic separation and spectrophotometric analysis of the methoxy-catecholamines.

Submitted on May 26, 1966
Accepted on July 14, 1966







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Copyright © 1966 by the American Association for Clinical Chemistry.