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Clinical Chemistry 12: 314-318, 1966;
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Clinical Chemistry, Vol 12, 314-318, Copyright © 1966 by the American Association for Clinical Chemistry

Detection of Brominism by an Automated Chloride Method

J. L. Driscoll 1 and H. F. Martin 1

1 Department of Pathology, Rhode Island Hospital, Providence, R. I. 02902.

In the performance of routine determinations of serum chloride by the automated method, which depends on halide displacement of mercury from the thiocyanate to allow formation of ferric thiocyanate complex, 4 cases of bromide poisoning were detected. Experimental evidence shows the halide substitution to be an equilibrium, with higher formation constants for the heavier halide ions. As a result, the chloride determination simultaneously becomes a screen for brominism since the presence of appreciable quantities of bromide ion in serum will produce apparently high chloride values.

Submitted on July 7, 1965
Accepted on January 5, 1966




The following articles in journals at HighWire Press have cited this article:


Home page
 J Child NeurolHome page
R. C. Woody
Bromide Therapy for Pediatric Seizure Disorder Intractable to Other Antiepileptic Drugs
J Child Neurol, January 1, 1990; 5(1): 65 - 67.
[Abstract] [PDF]


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Copyright © 1966 by the American Association for Clinical Chemistry.