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Clinical Chemistry, Vol 13, 542-553, Copyright © 1967 by the American Association for Clinical Chemistry
1 Unit of Experimental Medicine, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Mass. 02139.
Familial goiter with hypothyroidism can be subdivided into at least 8 groups and each appears to result from an inherited disorder at a specific stage in thyroid hormone synthesis, mobilization, or peripheral effect. At times, the intense hyperplasia which accompanies one of these disorders evolves into malignant disease. Criteria for diagnosis of each are presented.
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