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Clinical Chemistry 16: 602-605, 1970;
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Clinical Chemistry, Vol 16, 602-605, Copyright © 1970 by the American Association for Clinical Chemistry

Atomic Absorption Spectrophotometry of Rubidium in Biological Fluids

E. Sutter 1, S. R. Platman 1, and R. R. Fieve 1

1 Department of Psychiatry, Columbia University, and the Clinical and Metabolic Research Laboratory, New York State Psychiatric Institute, 722 W. 168th St., New York, N.Y. 10032.

The atomic absorption spectrophotometric method for measurement of rubidium in serum, plasma, whole blood, and urine was evaluated, and the effects of interfering ions were studied. Absorbance was most enhanced by potassium and sodium; calcium, bicarbonate, and chloride at the concentrations found in serum did not affect rubidium absorption. Naturally occurring rubidium concentrations in serum, plasma, whole blood, and urine are 3, 4, 70, and 18 µEq/liter, respectively, much lower than expected therapeutic concentrations. Methods for preparing standards, optimum instrument settings, and special treatment of samples were established with specimens from monkeys treated with rubidium. These procedures are applicable to human bloods from patients receiving rubidium therapy when such therapy is begun for treatment of affective disorders.


Key Words: normal values • potassium and sodium enhancing effect • standard and sample preparation • blood, serum, plasma, and urine

Submitted on August 7, 1969
Accepted on May 14, 1970






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Copyright © 1970 by the American Association for Clinical Chemistry.