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Clinical Chemistry 17: 135-144, 1971;
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Clinical Chemistry, Vol 17, 135-144, Copyright © 1971 by the American Association for Clinical Chemistry

Molecular Heterogeneity of Human Serum Cholinesterase

Rudolph V. LaMotta 1 and Charles L Woronick 1

1 Medical Research Laboratories, Department of Medicine, Hartford Hospital, Hartford, Conn. 06115.

The evidence is described that serum cholinesterases are a group of discrete isoenzymes, differing primarily in molecular size but also kinetically. A number of genetically determined variants have been described which probably differ by virtue of structural modifications. The clinical importance of the measurement of serum cholinesterase activity is discussed.


Key Words: acetylcholinesterase • genes directing biosynthesis • molecular variants • isoenzymes • electrophoretic separation

Submitted on October 29, 1970
Accepted on November 2, 1970






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Copyright © 1971 by the American Association for Clinical Chemistry.