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Clinical Chemistry 19: 258-261, 1973;
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Clinical Chemistry, Vol 19, 258-261, Copyright © 1973 by the American Association for Clinical Chemistry

Nonspecific Interferences in the Fluorometric Determination of Plasma Cortisol

Thomas R. Koch 1, Leila Edwards 1, and Max E. Chilcote 1

1 State University of New York at Buffalo, and Erie County Laboratories, Buffalo, N. Y. 14215.

The popular Mattingly [J. Clin. Pathol. 15, 374 (1962)] fluorometric assay for plasma cortisol is shown to give rise to falsely high values when performed with the recommended optical arrangement. By exciting at 470 nm, however, results are obtained that correlate well (r = 0.972) with those of competitive protein binding. The source of the interference is not identified, but it is related to both the dichloromethane used for extraction and the nature of the individual plasma sample.

Submitted on October 16, 1972
Accepted on November 14, 1972






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Copyright © 1973 by the American Association for Clinical Chemistry.