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Clinical Chemistry 19: 263-265, 1973;
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Clinical Chemistry, Vol 19, 263-265, Copyright © 1973 by the American Association for Clinical Chemistry

Some Drugs and Other Substances That Interfere with Protein Determination

D. H. Pashley 1, G. S. Schuster 1, P. Palmer 1, and M. M. Sharawy 1

1 Departments of Oral Biology, Physiology, and Cell and Molecular Biology, Medical College of Georgia, Schools of Dentistry and Medicine, Augusta, Ga. 30902.

We show that a variety of substances may interfere positively, to different extents, with the determination of protein by either the Lowry procedure or absorbance at 280 nm, or both. Some of these substances may interfere in concentrations that could be present in clinical laboratory specimens or in research samples.


Key Words: Folin—Ciocalteu reagent for proteins • Lowry method for proteins • ultraviolet measurement of proteins

Submitted on November 1, 1972
Accepted on December 5, 1972






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Copyright © 1973 by the American Association for Clinical Chemistry.