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Clinical Chemistry 19: 1040-1044, 1973;
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Clinical Chemistry, Vol 19, 1040-1044, Copyright © 1973 by the American Association for Clinical Chemistry

Gas Chromatography in Diagnostic Biochemistry of Abnormal Valine Metabolism

Hugh N. Tucker 1 and Samuel V. Molinary 1

1 Department of Biochemistry, Child Development Center, The University of Tennessee Medical Units, Memphis, Tenn. 38105.

Amino acids in biological fluids can be rapidly and accurately quantitated by gas chromatography. Modification of existing gas-chromatographic techniques allow as little as 25 µl of biological fluids to be analyzed, compatible with sample sizes easily obtained in pediatric studies. Simplified diagnostic biochemical evaluation of a suspected aminoaciduria can be begun at birth, or shortly after. Normal amino acid patterns are compared with those found in a patient with abnormal amino acid concentrations. Gas chromatographic evidence is presented as a diagnostic aid in the evaluation of a patient with abnormal valine metabolism.


Key Words: pediatric specimens • cation-exchange chromatography • normal values for infants • gas chromatography of amino acids in plasma, urine, CSF

Submitted on May 14, 1973
Accepted on June 22, 1973






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Copyright © 1973 by the American Association for Clinical Chemistry.