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Clinical Chemistry 19: 963-966, 1973;
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Clinical Chemistry, Vol 19, 963-966, Copyright © 1973 by the American Association for Clinical Chemistry

Gas-Chromatographic—Mass-Spectrometric Determination of Urinary Acid Profiles of Normal Young Adults. II. The Effect of Ethanol

Thomas A. Witten 1, Steven P. Levine 1, Mary T. Killian 1, Peter J. R. Boyle 1, and Sanford P. Markey 1

1 Gastroenterology Section, Department of Medicine, Veterans Administration Hospital, Denver, Colo. 80220 (T.A.W., S.P.L., M.T.K.); and the Department of Anatomy (P.J.R.B.) and the B. F. Stolinsky Laboratories, Department of Pediatrics (S.P.M.), University of Colorado Medical Center, Denver, Colo. 80220.

Urinary acid metabolic profiles of 26 healthy young adults who were maintained on a palatable standard diet for three days have been studied by combined gas chromatography-mass spectrometry. Means and standard deviations of the excretion rates of individual, identified acids were determined after the ingestion of ethanol and compared to basal values previously reported. A significant net effect of ethanol was demonstrated for only six of the acids studied: agr- and beta-hydroxybutyric, adipic, beta-methyladipic, p-hydroxyphenylacetic, and 2,5-furandicarboxylic acids.


Key Words: cirrhosis • individual variation in disease susceptibility • variables in effects of alcohol

Submitted on May 5, 1973
Accepted on May 21, 1973






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Copyright © 1973 by the American Association for Clinical Chemistry.