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Clinical Chemistry 2: 170-174, 1956;
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Clinical Chemistry, Vol 2, 170-174, Copyright © 1956 by the American Association for Clinical Chemistry

Absorption and Excretion of 17, 21-Dihydroxy-20-Ketosteroids in Dogs

Robert H. Silber 1 and Evan R. Morgan 1

1 Merck Institute for Therapeutic Research, Rahway, N. J.

The plasma concentrations of free 17,21-dihydroxy-20-ketosteroids and urinary excretion of both free and glucuronide forms have been determined after oral, intramuscular, and intravenous administration of cortisone, hydrocortisone, their delta1 forms, and 9alpha-fluorohydrocortisone to dogs.

Excretion of the glucuronide forms of those steroids with a double bond at the 1-2 position or with a fluorine at position 9 was depressed, and the plasma half-life of each of these steroids was longer than that of the parent compound.

Submitted on December 17, 1955






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Copyright © 1956 by the American Association for Clinical Chemistry.