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Clinical Chemistry 20: 81-83, 1974;
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Clinical Chemistry, Vol 20, 81-83, Copyright © 1974 by the American Association for Clinical Chemistry

Simultaneous Automated Estimation of Noradrenaline and Dopamine in Brain Tissue

P. Waldmeier 1, P. De Herdt 1, and L. Maitre 1

1 Research Department, Pharmaceuticals Division, Ciba-Geigy Limited, Basle, Switzerland.

Dr. P. Waldmeier, Research Department, Pharmaceuticals Division, Bldg. K-25, Room 601, Ciba-Geigy Limited, CH-4002 Basle, Switzerland.

A method is described for the simultaneous automated fluorometric estimation of noradrenaline and dopamine in brain extracts. It is based on a slight modification of the automated method for dopamine published recently. Interference of noradrenaline in the estimation of dopamine, and vice versa, is low (0.8 and 1.4%, respectively). Interferences of other catechols and related compounds have also been studied. Samples can be processed at a rate of 30 per hour, and the limit of sensitivity for both amines is about 2 ng/ml of brain extract.


Key Words: fluorometry • AutoAnalyzer • rats

Submitted on October 11, 1973
Accepted on November 3, 1973






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Copyright © 1974 by the American Association for Clinical Chemistry.