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Clinical Chemistry 20: 1292-1294, 1974;
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Clinical Chemistry, Vol 20, 1292-1294, Copyright © 1974 by the American Association for Clinical Chemistry

Rocket Immunoselection for Detection of Heavy-Chain Diseases

D. S. J. Gale 1, J. M. B. Versey 1, and John R. Hobbs 1

1 Department of Chemical Pathology, Westminster Medical School, London SW1P 2AR.

A method is described that allows heavy-chain disease proteins to be simply detected. The sample is electrophoresed in an agarose plate containing kappa and lambda antisera in the lower section, and the relevant heavy-chain antisera in the upper section. Light chains and immunoglobulins containing light chains are precipitated in the lower region. Free "heavy chains" migrate into the upper region, where they are precipitated as a separate rocket. The method is quick, sensitive, and requires little antiserum.


Key Words: diagnosis of cancer • electroimmunoassay • Laurell immunoelectrophoresis • monoclonal gammopathy

Submitted on May 13, 1974
Accepted on July 25, 1974




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Copyright © 1974 by the American Association for Clinical Chemistry.