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Clinical Chemistry 20: 1446-1450, 1974;
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Clinical Chemistry, Vol 20, 1446-1450, Copyright © 1974 by the American Association for Clinical Chemistry

Thin-Layer Chromatographic Screening of Amino Acids in Plasma and Urine of Newborns

Bernard Century 1, William P. Vorkink 1, and Samuel Natelson 1

1 Department of Biochemistry, Michael Reese Medical Center, 29th St. and Ellis Ave., Chicago, Ill. 60616.

We describe a simple, rapid, and inexpensive unidimensional high-resolution thin-layer chromatographic procedure for screening for aminoacidopathies in newborns. Protein-free filtrates are prepared for ultrafiltration of as little as 10 µl of plasma. A rapid, inexpensive photographic method provides large, high-contrast pictures of the chromatograms for permanent records. A day’s samples can be completed in 3 h, including all phases of the procedure.


Key Words: tyrosinemia in premature infants • photographic records of chromatograms • inherited disorders

Submitted on July 13, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.