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Clinical Chemistry 20: 1466-1469, 1974;
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Clinical Chemistry, Vol 20, 1466-1469, Copyright © 1974 by the American Association for Clinical Chemistry

Increased Synthesis of Lactate Dehydrogenase "H" Subunit by a Malignant Tumor

Arthur R. Henderson M. B., Ph.D.1, Dildar Ahmad L.R.C.P.1, and Doris McKenzie A.R.T.1

1 Department of Clinical Biochemistry and Department of Medicine, University Hospital (University of Western Ontario), London, Ontario N6G 2K3, Canada.

In a patient with a rapidly growing malignant teratoma in the anterior mediastinum, the only biochemical abnormality detected at first was an abnormally high serum lactate dehydrogenase (EC 1.1.1.27) activity, almost 50% of the activity being present in lactate dehydrogenase isoenzyme-1 (LD1). At the time of death, the total lactate dehydrogenase activity had increased still further, 77% of it being in the LD1 fraction. Both the tumor and its hepatic metastases were shown to have a supranormally active LD1 fraction. These patterns appear to be attributable to an increased synthesis of the "H" subunit by the tumor.

Submitted on July 31, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.