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Clinical Chemistry 20: 217-221, 1974;
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Clinical Chemistry, Vol 20, 217-221, Copyright © 1974 by the American Association for Clinical Chemistry

Microsampling for Blood-Lead Analysis

M. P. Bratzel Jr. 1 and A. Jane Reed 1

1 Community Environmental Management Activity, Bureau of State Services, Center for Disease Control, Atlanta, Ga. 30333.

We detail the technique, procedure, and equipment required to properly obtain a micro-scale capillary (fingerstick) blood specimen for subsequent determination of its lead content. We divide the microsampling procedure into preparation of sampling equipment and subject, the fingerstick, micro blood collection devices, and transport and storage. The concept of a total-system approach to quality control for sampling and analysis is presented. For realistic quality control, the sampling component and the analysis component are inseparable. We describe types and sources of errors encountered. Most of the variability in the total system is associated with sampling.


Key Words: toxicology • trace elements • environmental hazards • mass-screening technique • sample contamination

Submitted on August 20, 1973
Accepted on November 14, 1973






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Copyright © 1974 by the American Association for Clinical Chemistry.