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Clinical Chemistry 20: 424-427, 1974;
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Clinical Chemistry, Vol 20, 424-427, Copyright © 1974 by the American Association for Clinical Chemistry

Design and Performance of a Miniaturized High-Speed Continuous-Flow Analyzer

William E. Neeley 1, Stephen C. Wardlaw 2, and Helen C. Sing 1

1 Division of Biochemistry, Walter Reed Army Institute of Research, Washington, D. C. 20012.
2 Department of Laboratory Medicine, Yale-New Haven Hospital, New Haven, Conn. 06510.

Design features and performance of a miniaturized high-speed continuous-flow analyzer are described. Special emphasis is made in the design towards a system that is free from the operational and mechanical complexities found in most of today’s advanced systems. Depending on the particular analyses, sample size varies from 3 to 25 µl and reagent consumption is less than 180 µl per sample. Analyses are performed under steady-state conditions at sampling rates of 150 samples per hour with a 2:1 or 3:1 sample-to-wash ratio. The marked reduction in sample size makes the system ideal for microanalyses, especially in the pediatric clinical laboratory, in small animal research, and in any other cases where small sample volume is especially important.


Key Words: glucose and total protein determinations as representative of results • pediatric chemistry • AutoAnalyzer

Submitted on December 5, 1973
Accepted on January 11, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.