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Clinical Chemistry 20: 465-469, 1974;
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Clinical Chemistry, Vol 20, 465-469, Copyright © 1974 by the American Association for Clinical Chemistry

Quantitative Analysis of Morphine in Urine by Gas Chromatography-Chemical Ionization-Mass Spectrometry, with [N-C2H3]Morphine as an Internal Standard

Pauline A. Clarke 1 and Rodger L. Foltz 1

1 Battelle, Columbus Laboratories, 505 King Ave., Columbus, Ohio 43201.

A highly sensitive and specific method is described for quantitative determination of morphine in urine. Used in the method is a gas chromatograph and a computerized, quadrupole mass spectrometer operated under chemical ionization conditions. Morphine concentrations as low as 5 ng/ml can be measured by selected ion monitoring, with N-trideuteromethyl morphine as the internal standard. The sensitivity and specificity of the method is illustrated by the detection and quantitation of morphine in urine after ingestion of cough medicine containing codeine.

Submitted on October 19, 1973
Accepted on January 29, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.