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Clinical Chemistry 20: 574-575, 1974;
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Clinical Chemistry, Vol 20, 574-575, Copyright © 1974 by the American Association for Clinical Chemistry

New Method for Measurement of Guanidinosuccinic Acid in Serum and Urine

J. Gróf 1, A. Tankó 1, and J. Menyhárt 1

1 Research Unit of the Hungarian Academy of Sciences, Department of Urology, Semmelweis Medical School, Budapest, Hungary.

We describe a new method for measurement of guanidinosuccinate in serum and urine. To separate it from interfering guanidino compounds, it is adsorbed on and eluted from an anion-exchange column. The modified method requires less serum and is considerably faster than previous ones.


Key Words: hemodialysis • anion-exchange chromatography • Sakaguchi reàction • uremia

Submitted on August 16, 1973
Accepted on February 26, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.