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Clinical Chemistry 20: 576-581, 1974;
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Clinical Chemistry, Vol 20, 576-581, Copyright © 1974 by the American Association for Clinical Chemistry

Evaluation of a Transformation Method for Estimation of Normal Range

Allen H. Reed 1 and Gaw Tzu Wu 1

1 Bio-Science Laboratories, 7600 Tyrone Ave., Van Nuys, Calif. 91405.

We have evaluated a recently proposed method for estimating normal limits by prior transformation of data to gaussian-like form. Computer simulation techniques are used to generate random data from frequency distributions having various shapes. For each such distribution, the transformation method is compared with the method of nonparametric percentile estimation. We conclude that the nonparametric method should continue to be the method of choice unless data have a nearly symmetrical frequency distribution. The present state of methods for estimating normal ranges is discussed.


Key Words: computers • statistics • data processing • nonparametric methods

Submitted on December 10, 1973
Accepted on February 27, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.