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Clinical Chemistry 20: 595-602, 1974;
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Clinical Chemistry, Vol 20, 595-602, Copyright © 1974 by the American Association for Clinical Chemistry

Evaluation of the Adaptation of the Glucose Oxidase/Peroxidase-3-Methyl-2-benzothiazolinone hydrazone-N, N-Dimethylaniline Procedure to the Technicon "SMA 12/60," and Comparison with Other Automated Methods for Glucose

R. Neill Carey 1, Donald Feldbruegge 1, and James O. Westgard 1

1 University of Wisconsin Center for Health Sciences, Departments of Pathology and Medicine, Madison, Wis. 53706.

We have evaluated the Technicon SMA 12/60 modification of a glucose oxidase/peroxidase-3-methyl-2-benzothiazolinone hydrazone-N, N-dimethylaniline method, and find it acceptable. Added bilirubin, creatinine, dextrans, and uric acid did not interfere. We compared values for patients’ sera by this method to those by the glucose oxidase/peroxidase-2,2'-azinodiethylbenzothiazoline-6-sulfonic acid, neocuproine, o-toluidine, ferricyanide, and hexokinase methods. For comparisons to the hexokinase method (which we used as a reference method), n = 371, slope = 1.00, y-intercept = 1.57 mg/dl, and bias = 2.05 mg/dl. For the method being evaluated, the run-to-run average monthly standard deviation was 2.9 mg/dl for a control product for which the mean was 85 mg of glucose per deciliter, and 4.3 mg/dl for a product for which the mean was 240 mg/dl. All six methods were compared for effects of uremic sera, icteric sera, and sera from patients receiving ascorbic acid therapy or hypoglycemic drugs.


Key Words: comparison with five other methods for serum glucose • sources of variation • AutoAnalyzer • urinary glucose • normal values • age-related increase in serum glucose • acceptable analytical error, random and systematic • interference studies • " kit" method • Du Pont ACA

Submitted on December 18, 1973
Accepted on February 22, 1974




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[Abstract] [Full Text] [PDF]


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Copyright © 1974 by the American Association for Clinical Chemistry.