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Clinical Chemistry 20: 607-610, 1974;
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Clinical Chemistry, Vol 20, 607-610, Copyright © 1974 by the American Association for Clinical Chemistry

Interference with Measurement of 3-Methoxy-4-hydroxymandelic Acid and 5-Hydroxyindoleacetic Acid by Reducing Metabolites

Jerome M. Feldman 1, Susan S. Butler 1, and Barbara A. Chapman 1

1 Durham Veterans Administration Hospital, and Division of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, N. C. 27710.

Using standard analytical techniques, we noted a decrease in the urinary excretion of 3-methoxy-4-hydroxymandelic acid and 5-hydroxyindoleacetic acid in a patient with alcaptonuria, and in subjects receiving aspirin or L-dopa [3-( 3,4-dihydroxyphenyl)-L-alanine]. This apparent decrease in excretion of the two compounds is an artifact produced by metabolites in urine, such as homogentisic acid, gentisic acid, 3,4-dihydroxyphenylacetic acid, or homovanillic acid.


Key Words: alcaptonuria • dihydroxyphenylacetic acid • homovanillic acid • homogentisic acid • diagnosis of pheochromocytoma or carcinoid tumor

Submitted on October 2, 1973
Accepted on February 15, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.