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Clinical Chemistry 20: 615-616, 1974;
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Clinical Chemistry, Vol 20, 615-616, Copyright © 1974 by the American Association for Clinical Chemistry

Specific Gravity of Blood and Plasma at 4 and 37 °C

Raymond J. Trudnowski 1 and Rodolfo C. Rico 1

1 Department of Anesthesiology, Roswell Park Memorial Institute, New York State Department of Health, 666 Elm St., Buffalo, N. Y. 14203.

The specific gravity (relative density) of human whole blood and plasma from 25 healthy volunteers was determined gravimetrically. For whole blood it was found to be 1.0621 (95% confidence interval: 1.0652-1.0590) at 4 °C and 1.0506 (95% confidence interval: 1.0537-1.0475) at 37 °C. Plasma specific gravity was 1.0310 (95% confidence interval: 1.0324-1.0296) at 4 °C and 1.0205 (95% confidence interval: 1.0216-1.0193) at 37 °C. All of these values are referred to the density of water at 4 °C. We show the relationship between these values and those given in the literature for measurements at 25 °C. There was a small increase in whole blood specific gravity with increasing hematocrit, but it was not statistically significant over the 40-56 hematocrit range studied.

Submitted on January 28, 1974
Accepted on February 25, 1974




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Copyright © 1974 by the American Association for Clinical Chemistry.