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Clinical Chemistry 21: 1393-1395, 1975;
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Clinical Chemistry, Vol 21, 1393-1395, Copyright © 1975 by the American Association for Clinical Chemistry

Influence of Age, Sex, and Oral Contraceptives on Human Blood Cholinesterase Activity

Frederick R. Sidell 1 and Andris Kaminskis 1

1 Clinical Research Branch, Medical Research Division, Biomedical Laboratory, Edgewood Arsenal, Md. 21010.

We estimated cholinesterase (EC 3.1.1.8) activities in erthrocytes and plasma of 443 men, 188 women not taking oral contraceptives, and 70 women who were taking oral contraceptives. Men in the first six decades of life had higher plasma cholinesterase activity than did women who were not taking oral contraceptives, and these women had higher plasma cholinesterase activity than women taking oral contraceptives. After the age of 60 there was no intersex difference. Activity of erythrocytes from the oral contraceptive group was higher than in the other groups, men had the lowest activity, and there was an increased activity with age in both sexes until the age of 60. These findings suggest that there is no single "normal" value for cholinesterase activity for adults.


Key Words: normal (reference) values • enzyme activity • variation, source of

Submitted on April 21, 1975
Accepted on May 22, 1975




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