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Clinical Chemistry 21: 1396-1405, 1975;
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Clinical Chemistry, Vol 21, 1396-1405, Copyright © 1975 by the American Association for Clinical Chemistry

Trend Detection in Control Data: Optimization and Interpretation of Trigg's Technique for Trend Analysis

George S. Cembrowski 1, James O. Westgard 1, Arthur A. Eggert 1, and E. Clifford Toren Jr. 1

1 Departments of Medicine, Pathology, and the Clinical Laboratories, University of Wisconsin Center for Health Sciences, 1300 University Ave., Madison, Wis. 53706.

A method for trend detection, Trigg's technique [Oper. Res. Q. 15, 271 (1964)], has been investigated for use in monitoring trends in control data produced by multitest continuous-flow analyzers. Simulated trend data were used to optimize the method. Actual control data were analyzed retrospectively to determine the frequency of trends and the accuracy of several parameters obtained from Trigg's method. The prospective use of the technique has successfully uncovered important trends. Criteria for the interpretation of the Trigg's trend data are suggested and an algorithm for the computer implementation of Trigg’s calculations is included.


Key Words: statistics • Levey—Jennings plot • cusum values • continuous-flow analysis • quality control • computers

Submitted on April 7, 1975
Accepted on May 17, 1975




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