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Clinical Chemistry 21: 1601-1604, 1975;
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Clinical Chemistry, Vol 21, 1601-1604, Copyright © 1975 by the American Association for Clinical Chemistry

Chromatographic and Electrophoretic Separation of Creatine Kinase Isoenzymes Compared

Gifford Lum 1 and Arthur L. Levy 1

1 Chemistry Laboratory, St. Vincent’s Hospital and Medical Center of New York, 153 W. 11th St., New York, N. Y. 10011

We compared two techniques for separating and evaluating serum creatine kinase isoenzymes—fluorometric agarose electrophoresis and Sephadex chromatography—in 50 patients, 25 of whom had confirmed acute myocardial infarction. In every case isoenzyme MB (heart isoenzyme) was detected with equal sensitivity by either procedure. Evidently, only the presence or absence of MB is clinically significant; none of the 25 patients without infarction had detectable MB activity in their serum. Columns connected to a continuous-flow sample line for analyses of the eluting stream without further modification produced satisfactory results


Key Words: myocardial infarction • diagnostic aids • enzyme activity

Submitted on April 30, 1975
Accepted on July 11, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.