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Clinical Chemistry 21: 1683-1685, 1975;
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Clinical Chemistry, Vol 21, 1683-1685, Copyright © 1975 by the American Association for Clinical Chemistry

Laboratory Diagnosis of Bence Jones Proteinuria in a Patient with Plasma Cell Leukemia

Chiman Chow Ph.D.1 and Ralph W. Spitzer Ph.D., M.D.1

1 Department of Laboratories, Lions Gate Hospital, 230 East 13th St., North Vancouver, B.C. Canada; and Department of Laboratories, Royal Columbian Hospital, 330 East Columbia Street, New Westminster, B.C. Canada

Kappa Bence Jones proteinuria was found by immunoelectrophoretic techniques in a patient with plasma cell leukemia, who presented with no M-proteins either in serum or urine. However, a significant decrease in normal immunoglobulins was observed. On microscopic examination of kidney sections obtained at autopsy, protein casts were seen in the distal tubules. Bence Jones protein was not detected by the conventional heat test

Submitted on June 10, 1975
Accepted on July 9, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.