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Clinical Chemistry 21: 1899-1902, 1975;
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Clinical Chemistry, Vol 21, 1899-1902, Copyright © 1975 by the American Association for Clinical Chemistry

Fluorometric Assay for N-Acetylprocainamide

Edward Matusik 1 and Thomas P. Gibson 1

1 Division of Biochemistry and Department of Nephrology, Walter Reed Army Institute of Research, Washington, D. C. 20012.

We describe a simple, rapid fluorometric assay for separate quantitative analysis of procainamide and N-acetylprocainamide in mixtures. The effective linear range (fluorescence vs. concentration) in serum is 0.1 to 10.0 mg/liter, regardless of the ratio (by weight) of the two drugs from 1:10 to 10:1. Analytical recoveries by the extraction method used were 100.0 ± 3.0% and 98.0 ± 4.0%, respectively. For determination of either compound, the maximum coefficient of variation was 10%.


Key Words: drug assay • pKa • quantum yield

Submitted on July 7, 1975
Accepted on September 20, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.