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Clinical Chemistry 21: 1964-1969, 1975;
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Clinical Chemistry, Vol 21, 1964-1969, Copyright © 1975 by the American Association for Clinical Chemistry

5-Decynedioic Acid, an Acetylenic Compound in Human Urine

Sven Lindstedt 1 and Göran Steen 1

1 Department of Clinical Chemistry, University of Gothenburg, Sahlgren's Hospital, S-413 45 Gothenburg, Sweden.

An acetylenic dicarboxylic acid, 5-decynedioic acid, has been isolated from human urine. The structure was determined by mass spectrometry of several derivatives, and by infrared spectroscopy. On osmium tetroxide oxidation, a vic-diketone was formed, the mass spectrum of which established the position of the triple bond between carbon atoms 5 and 6. Mass spectrometric evidence for the presence of a small amount of the isomeric 4-decynedioic acid was also obtained. The 24-h excretion of these acids is 0.01-0.1 mmol for healthy adults on a regular diet.


Key Words: normal values • ketosis • 4-decynedioic acid

Submitted on August 20, 1975
Accepted on October 1, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.