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Clinical Chemistry 21: 551-557, 1975;
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Clinical Chemistry, Vol 21, 551-557, Copyright © 1975 by the American Association for Clinical Chemistry

Intercomparison Program of Lead, Mercury, and Cadmium Analysis in Blood, Urine, and Aqueous Solutions

Robert Lauwerys 1, Jean-Pierre Buchet 1, Harry Roels 1, Alexander Berlin 2, and Jan Smeets 2

1 Unité de Toxicologie Industrielle et Médicale, University of Louvain, Clos Chapelle-aux-Champs 4, B-1200 Brussels, Belgium.
2 The Commission of the European Communities, Centre Louvigny, 23 Avenue Monterey, (Grand Duché) Luxembourg

Sixty-six European laboratories participated in an intercomparison program of lead, mercury, and cadmium analysis in blood, urine, and aqueous solutions. The experimental protocol was designed in such a way that the effect of precision, experience, and analytical method could be evaluated. For all the analyses, the scatter of the reported results is important. The major factor influencing the variability of the results is the intralaboratory variation. Analytical methods and degree of experience do not seem to have a significant influence. However, with the exception of mercury determination in urine, a satisfactory intralaboratory precision is not sufficient to make the interlaboratory variation acceptable. It appears that systematic errors are responsible for the high interlaboratory variation observed between "precise" laboratories.


Key Words: inter- and intralaboratory performance • toxicology • effect of technique used, experience, laboratory precision • analytical error • trace elements

Submitted on January 7, 1975




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Copyright © 1975 by the American Association for Clinical Chemistry.