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Clinical Chemistry 21: 568-577, 1975;
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Clinical Chemistry, Vol 21, 568-577, Copyright © 1975 by the American Association for Clinical Chemistry

Serum and Tissue Enzyme Activity and Trace-Element Content in Response to Zinc Deficiency in the Pig

Robert E. Burch 1, Robert V. Williams 1, Henry K. J. Hahn 1, Mary M. Jetton 1, and James F. Sullivan 1

1 Veterans Administration Hospital, 4101 Woolworth Ave.; and the Department of Medicine, Creighton University School of Med icine, Omaha, Neb. 68105.

Zinc deficiency is associated with poor growth and development. It has been postulated that a deficiency of the various zinc metalloenzymes results from the lack of dietary zinc. From present study, an examination of some aspects of this postulate, we conclude the following about zinc deficiency in pigs: (1) Of the tissues studied, it results in diminished zinc content only in liver, kidney, and pancreas. (2) It is associated with tissue ab normalities of various trace elements other than zinc. (3) Histochemical enzyme assays are satisfactory for qualitative but not quantitative determination of zinc me talloenzymes. (4) Deficiency of various tissue zinc metalloenzymes is difficult to demonstrate, even in severezinc deficiency. (5) It is associated with decreased activity of hepatic leucine aminopeptidase and ornithine transcarbamylase, and decreased serum cholesterol concentrations. Our findings are consistent with the postulate that alterations in a number of trace elements may occur in the entity called zinc deficiency.


Key Words: pigs • zinc-deficiency syndrome • hepatic leucine aminopeptidase and ornithine transcarbamylase • enzyme activity and zinc deficiency • effect of zinc deficiency on other trace elements, serum cholesterol • trace elements in tissues • histochemically assessing enzymatic activity in tissues • atomic absorption spectrophotometry • organ-specific changes in trace elements

Submitted on December 22, 1974
Accepted on January 27, 1975




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Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells
Am J Physiol Cell Physiol, August 1, 2002; 283(2): C623 - C630.
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Apolipoprotein A-I gene expression is regulated by cellular zinc status in Hep G2 cells
Am J Physiol Cell Physiol, September 1, 1999; 277(3): C537 - C544.
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Copyright © 1975 by the American Association for Clinical Chemistry.