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Clinical Chemistry 21: 578-581, 1975;
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Clinical Chemistry, Vol 21, 578-581, Copyright © 1975 by the American Association for Clinical Chemistry

Influence of Myocardial Infarction on Serum Manganese, Copper, and Zinc Concentrations

Jacques Versieck 1, Fabrice Barbler 1, Albert Speecke 1, and Julien Hoste 1

1 Department of Internal Medicine, Academic Hospital, De Pintelaan 135, B-9000 Ghent; and Laboratory for Analytical Chemistry, Institute for Nuclear Sciences, Proeftuinstraat 86, B-9000 Ghent (both are divisions of the State University of Ghent, Belgium).

Reportedly, serum manganese concentrations increase after myocardial infarction, closely correlated with increased serum aspartate aminotransferase activity. However, these conclusions are apparently based on analyses of contaminated samples. Serum manganese concentrations after myocardial infarction have been re-investigated by neutron activation analysis, and no significant increase could be demonstrated. Because serum copper and zinc could be determined simultaneously, analyses for these trace elements are also reported, which confirm the findings of others. After myocardial Infarction a statistically significant (0.02 < P < 0.05) increase in serum copper and a statistically significant (0.001 < P < 0.01) decrease in serum zinc were observed.


Key Words: neutron activation analysis

Submitted on October 23, 1974
Accepted on January 28, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.