Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 21: 1121-1127, 1975;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McLaren, G. D.
Right arrow Articles by Nino, H. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McLaren, G. D.
Right arrow Articles by Nino, H. V.

Clinical Chemistry, Vol 21, 1121-1127, Copyright © 1975 by the American Association for Clinical Chemistry

Erythrocyte Protoporphyrin in the Detection of Iron Deficiency

Gordon D. McLaren 1, John T. Carpenter Jr. 1, and Hipolito V. Nino 1

1 Nutritional Biochemistry Section of the Bureau of Laboratories, Center for Disease Control, Public Health Service, U.S. Department of HEW, Atlanta, Ga. 30333; and the Department of Medicine (Hematology), Emory University School of Medicine, Atlanta, Ga.

Center for Disease Control (Attn: H. V. Nino), Bureau of Laboratories, Clinical Chemistry Division, Analytical Biochemistry Branch, Nutritional Biochemistry Section, Atlanta, Ga. 30333.

Any decrease in the availability of iron for incorporation into the heme moieties of hemoglobin results in an increase in the erythrocyte protoporphyrin concentration. Our aim was to compare protoporphyrin concentrations, determined spectrophotometrically, with body iron stores, as assessed from the amount of iron demonstrable by Prussian blue staining of bone marrow aspirates. The mean protoporphyrin concentration (175 µg/dl) in the erythrocytes of a group of patients with markedly decreased stainable marrow iron or no iron Was Significantly Greater (P < .001) than the mean concentration (76 µg/dl) in a comparable group with adequate bone marrow iron stores, except in the presence of certain interfering conditions. These results suggest that the erythrocyte protoporphyrin test may be a useful addition to the methods now available for assessing disorders of heme synthesis, the most common of which is iron deficiency.


Key Words: bone marrow iron • diagnostic aids • lead exposure • method evaluation • nutritional biochemistry • population surveys

Submitted on March 14, 1975
Accepted on April 30, 1975




The following articles in journals at HighWire Press have cited this article:


Home page
 StrokeHome page
M. Mehdiratta, S. Kumar, D. Hackney, G. Schlaug, and M. Selim
Association Between Serum Ferritin Level and Perihematoma Edema Volume in Patients With Spontaneous Intracerebral Hemorrhage
Stroke, April 1, 2008; 39(4): 1165 - 1170.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
I J Griffin, M M Reid, K P B McCormick, and R J Cooke
Zinc protoporphyrin/haem ratio and plasma ferritin in preterm infants
Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2002; 87(1): F49 - 51.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. F. Labbe, H. J. Vreman, and D. K. Stevenson
Zinc Protoporphyrin: A Metabolite with a Mission
Clin. Chem., December 1, 1999; 45(12): 2060 - 2072.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1975 by the American Association for Clinical Chemistry.