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Clinical Chemistry 21: 1225-1233, 1975;
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Clinical Chemistry, Vol 21, 1225-1233, Copyright © 1975 by the American Association for Clinical Chemistry

Development of a Multipurpose Optical System for Use with a Centrifugal Fast Analyzer

C. A. Burtis 1, W. D. Bostick 1, and W. F. Johnson 1

1 Oak Ridge National Laboratory,1 Oak Ridge, Tenn. 37830.

A Centrifugal Fast Analyzer is basically a sophisticated photometric measuring device containing a multicuvet rotor as its major component. Several reactions are simultaneously initiated in the rotor, which is then rotated through a stationary optical monitor and the resulting signals acquired and processed by an on-line data system. With the miniature version of this analyzer, one has the option of directing the incident optical beam, via a fiber optical bundle, into the cuvets of the spinning rotor in either a 90° or a 180° orientation relative to the analyzer's photodetector. The combination of newly designed rotors and a flexible optical system having multiple configurations has provided a versatile system in which one can measure the transmittance, fluorescence, chemiluminescence, or light-scattering (either turbidimetrically or nephelometrically) properties of the ensuing reaction species, all with a single analyzer. This flexibility in choosing the optical mode in which a particular set of reactions is to be monitored provides the analyst with a powerful and versatile analytical tool for developing new methods for use in various clinical laboratory applications, including chemistry, toxicology, immunology, and hematology.


Key Words: multiple rotor designs • analytical versatility • spectrophotometer • spectrofluorometer • nephelometer • turbidimetric measurements • chemiluminescence • fiber optics

Submitted on April 10, 1975
Accepted on April 28, 1975




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[Abstract] [Full Text] [PDF]


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Copyright © 1975 by the American Association for Clinical Chemistry.