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Clinical Chemistry 21: 1253-1257, 1975;
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Clinical Chemistry, Vol 21, 1253-1257, Copyright © 1975 by the American Association for Clinical Chemistry

Stable Isotope Ratiometer-Multiple Ion Detector Unit for Quantitative and Qualitative Stable Isotope Studies by Gas Chromatography-Mass Spectrometry

Peter D. Klein 1, Joseph R. Haumann 1, and David L. Hachey 1

1 Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Ill. 60439.

We have designed and constructed a stable isotope ratiometer-multipie ion detector unit, which can drive existing gas chromatograph-quadrupole or magnetic sector mass spectrometers to monitor up to six ions in turn. Each of the three pairs of ions can be selected for quantitation; thus three different or successive components can be analyzed in a single gas-chromatographic run. A background subtraction option permits the ion intensity in the absence of sample to be subtracted automatically during sample measurement. Displays of accumulated counts and isotope ratio are updated twice per second during the measurement and can be printed out at its conclusion. All six ions can be monitored in the analog mode by parallel outputs to a multipen recorder. Experience gained in the construction of this prototype indicates that such units could be commercially available for $10 000, or about a third to a sixth of the cost of even an inexpensive computer system.

Submitted on March 4, 1975
Accepted on April 30, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.