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Clinical Chemistry 21: 1282-1287, 1975;
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Clinical Chemistry, Vol 21, 1282-1287, Copyright © 1975 by the American Association for Clinical Chemistry

Clinical Applications of Gas Chromatograph/Mass Spectrometer/Computer Systems

Marjorie G. Horning 1, Jean Nowlin 1, Carla M. Butler 1, Khing Lertratanangkoon 1, Kathleen Sommer 1, and Reba M. Hill 1

1 Institute for Lipid Research and Department of Pediatrics, Baylor College of Medicine, Houston, Tex. 77025.

Gas chromatograph/mass spectrometer/computer systems can be used to quantify a wide variety of compounds of clinical interest. A quadrupole instrument operated in the chemical ionization (Cl) mode was used in these studies. Because of the sensitivity and specificity of selective ion detection, it is possible to make measurements routinely in the nanogram to picogram range, with 0.1-1.0 ml samples of plasma and 1-5 ml samples of urine. Internal standards, preferably stable-isotopelabeled compounds, were added to the biological samples before isolation was begun. We describe clinical applications of these procedures to problems in toxicology, pharmacokinetics, and perinatal pharmacology.

Submitted on April 16, 1975
Accepted on June 3, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.