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Clinical Chemistry 23: 1849-1852, 1977;
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Clinical Chemistry, Vol 23, 1849-1852, Copyright © 1977 by American Association for Clinical Chemistry

Estimation of maprotiline in serum by gas-chromatography, with use of a nitrogen-specific detector

RN Gupta, G Molnar and ML Gupta

We describe a gas-chromatographic procedure for estimating therapeutic concentrations of maprotiline, a new tetracyclic antidepressant, in serum by use of a nitrogen-specific detector. Desmethyldoxepin, a secondary amine similar in structure to maprotiline, is added as a mass internal standard to the specimen before extraction, to obviate the need for accurate measurements of volumes during extraction and analysis. Both maprotiline and the internal standard are converted to acetyl derivatives, to avoid the adsorption of secondary amines on the column. A highly selective liquid phase is used, which allows a very good separation of desmethyldoxepin, maprotiline, desmethylmaprotiline, and the interferences from serum and reagents.


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 Hum Exp ToxicolHome page
A.H. Stead and A.C. Moffat
A Collection of Therapeutic, Toxic and Fatal Blood Drug Concentrations in Man
Human and Experimental Toxicology, January 1, 1983; 2(3): 437 - 464.
[Abstract] [PDF]


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Copyright © 1977 by the American Association for Clinical Chemistry.