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Clinical Chemistry 23: 1857-1867, 1977;
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Clinical Chemistry, Vol 23, 1857-1867, Copyright © 1977 by American Association for Clinical Chemistry

Performance characteristics of rules for internal quality control: probabilities for false rejection and error detection

JO Westgard, T Groth, T Aronsson, H Falk and CH de Verdier

When assessing the performance of an internal quality control system, it is useful to determine the probability for false rejections (pfr) and the probability for error detection (ped). These performance characteristics are estimated here by use of a computer stimulation procedure. The control rules studied include those commonly employed with Shewhart-type control charts, a cumulative sum rule, and rules applicable when a series of control measurements are treated as a single control observation. The error situations studied include an increase in random error, a systematic shift, a systematic drift, and mixtures of these. The probability for error detection is very dependent on the number of control observations and the choice of control rules. No one rule is best for detecting all errors, thus combinations of rules are desirable. Some appropriate combinations are suggested and their performance characteristics are presented.


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