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Clinical Chemistry 23: 1930-1932, 1977;
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Clinical Chemistry, Vol 23, 1930-1932, Copyright © 1977 by American Association for Clinical Chemistry

Presence of creatine kinase BB isoenzyme in some patients with prostatic carcinoma

RD Feld and DL Witte

We have observed creatine kinase isoenzyme BB in the sera of nine of 19 patients with Stage D carcinoma of the prostate. Its presence does not seem to correlate with acid phosphatase activity in serum or the presence of bone metastases as indicated by increased alkaline phosphatase activity in serum. Only three of the nine patients with BB isoenzyme activity detectable in their serum had abnormal values for total creatine kinase activity, but all had abnormal values for alkaline and acid phosphatase activity. All 10 patients with no BB isoenzyme detectable had abnormal acid phosphatase values; however, only seven had increased alkaline phosphatase values and only one had increased creatine kinase activity.




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Copyright © 1977 by the American Association for Clinical Chemistry.