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Clinical Chemistry 23: 2122-2126, 1977;
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Clinical Chemistry, Vol 23, 2122-2126, Copyright © 1977 by American Association for Clinical Chemistry

Albumin/calcium association at different pH, as determined by potentiometry

N Fogh-Andersen

Calcium binding by albumin was determined potentiometrically at physiological ionic strength and temperature as a function of pH. The binding data indicate at least 30 different binding sites with different association constants and different H+ interaction. One site appears to be responsible for the major binding at physiological pH and substance concentration of free calcium, together with three other sites that bind with less affinity.


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Copyright © 1977 by the American Association for Clinical Chemistry.