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Clinical Chemistry 23: 957-959, 1977;
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Clinical Chemistry, Vol 23, 957-959, Copyright © 1977 by American Association for Clinical Chemistry

Determination of acetaminophen and phenacetin in plasma by high- pressure liquid chromatography

GR Gotelli, PM Kabra and LJ Marton

We describe a sensitive and precise high-pressure liquid chromatographic method in which acetoacetanilide is used as the internal standard to simultaneously determine acetaminophen and phenacetin in plasma. Therapeutic as well as toxic concentrations can be determined on as little as 0.1 ml of plasma. Sample preparation is rapid and chromatography is complete in 5 min. Quantitation is accurate at 0.5 mg/liter concentration for both drugs. Day-to-day precision within 5% is attainable. Of 36 other drugs tested, only theophylline interfered, with the determination of acetaminophen.


The following articles in journals at HighWire Press have cited this article:


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 Hum Exp ToxicolHome page
D. Parker, J.P. White, D. Paton, and P.A. Routledge
Safety of Late Acetylcysteine Treatment in Paracetamol Poisoning
Human and Experimental Toxicology, January 1, 1990; 9(1): 25 - 27.
[Abstract] [PDF]

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 Hum Exp ToxicolHome page
J.A.E. Smith, I.D. Hine, P. Beck, and P.A. Routledge
Paracetamol Toxicity: is Enzyme Induction Important?
Human and Experimental Toxicology, December 1, 1986; 5(6): 383 - 385.
[Abstract] [PDF]


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Copyright © 1977 by the American Association for Clinical Chemistry.