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Clinical Chemistry 24: 32-35, 1978;
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Clinical Chemistry, Vol 24, 32-35, Copyright © 1978 by American Association for Clinical Chemistry

Improved radiochemical assay for carnitine and its derivatives in plasma and tissue extracts

JA Pace, RW Wannemacher Jr and HA Neufeld

We describe the measurement of carnitine and short-chain and long-chain acylcarnitines in perchloric acid extracts of liver and muscle. [1- 14C]Acetyl-CoA is used, and labeled acetylcarnitine is measured with a sensitivity of less than 1 to 50 nmol of L-carnitine per 50-microliter sample. Samples frozen at -20 degrees C lost no carnitine during several months. Analytical recovery of carnitine (5 nmol) added to 50- microliter perchloric acid extracts of liver was 103 +/- 2%. This method may be suitable for clinical applications such as screening patients with muscle and metabolic disorders.


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Copyright © 1978 by the American Association for Clinical Chemistry.