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Clinical Chemistry 24: 1131-1133, 1978;
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Clinical Chemistry, Vol 24, 1131-1133, Copyright © 1978 by American Association for Clinical Chemistry

Hexosaminidase A in amniotic fluid of Tay-Sachs fetuses

B Geiger, R Navon and R Arnon

Hexosaminidase A is present in relatively low concentrations in cell- free amniotic fluids from pregnancies with Tay-Sachs fetuses. This isoenzyme was determined by an immunological procedure, radial immunodiffusion, by which hexosaminidase A can be directly and specifically detected, even in the presence of excess amounts of hexosaminidase B. No hexosaminidase A could be detected by the same procedure in Tay-Sachs fetal tissues, implying that this isoenzyme in the amniotic fluid originates from the mother.




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Copyright © 1978 by the American Association for Clinical Chemistry.