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Clinical Chemistry 24: 1202-1204, 1978;
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Clinical Chemistry, Vol 24, 1202-1204, Copyright © 1978 by American Association for Clinical Chemistry

Effect of temperature on plasma renin samples

F Fyhrquist and L Puutula

Plasma renin activity was measured in parallel in Na2EDTA-contained plasma samples after storage at -20, 4, and 24 degrees C, and in the lyophilized state. In peripheral venous plasma from 22 hypertensive patients, the activity (range, 0.08-46.7 microgram/liter per hour) remained stable during three days of storage at 4 degrees C, but decreased to a variable extent when plasma was kept at 24 degrees C: in one day by 9.2%, two days by 25.6%, and three days by 74.0%. Values were the same for samples handled at room temperature and chilled to 4 degrees C within 3 h and parallel samples immediately cooled in an icebath and kept at 4 degrees C. Freezing (-20 degrees C) and thawing of plasma was associated with a 22% mean increase in activity (range, 0- 83%). Lyophilization resulted in a smaller increase of plasma renin activity (mean 12%, range 0-46%). Blood for renin analysis need not be cooled immediately, but must be cooled to 4 degrees C within 2-3 h. It then is stabe for at least three days. Freezing or lyophilization appears to be associated with some cold activation of "prorenin."


The following articles in journals at HighWire Press have cited this article:


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 Clin. Chem.Home page
J. H. A. Roding, T. Weterings, and C. van der Heiden
Plasma Renin Activity: Temperature Optimum at ~45 {degrees}C
Clin. Chem., July 1, 1997; 43(7): 1243 - 1244.
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