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Clinical Chemistry 24: 1207-1212, 1978;
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Clinical Chemistry, Vol 24, 1207-1212, Copyright © 1978 by American Association for Clinical Chemistry

Marked hyperamylasemia associated with carcinoma of the lung

JG Flood, C Schuerch, RC Dorazio and GN Bowers Jr

We present a case of marked hyperamylasemia associated with undifferentiated small cell carcinoma of the lung. The serum alpha- amylase had an electrophoretic mobility similar to that of salivary gland enzyme (s-type), and that in tissue extracts from the lung tumor and metastatic skin nodules showed similar migration. No evidence of a salivary or pancreatic cause of hyperamylasemia was found at autopsy, and macroamylasemia was excluded. We suggest that the strikingly increased serum alpha-amylase activity was a result of ectopic production of this enzyme by tumor. We compare results for this case to other published reports.


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G. Benedetti, F. Rastelli, S. Damiani, C. Calandri, and L. Crino
Challenging Problems in Malignancy: CASE 1. Presentation of Small-Cell Lung Cancer With Marked Hyperamylasemia
J. Clin. Oncol., September 15, 2004; 22(18): 3826 - 3828.
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