Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 25: 777-779, 1979;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jatlow, P.
Right arrow Articles by Hochster, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jatlow, P.
Right arrow Articles by Hochster, H.

Clinical Chemistry, Vol 25, 777-779, Copyright © 1979 by American Association for Clinical Chemistry

Improved liquid-chromatographic determination of propranolol in plasma, with fluorescence detection

P Jatlow, W Bush and H Hochster

We describe an analysis for propranolol in plasma, with use of reversed- phase "high-pressure" liquid chromatography and fluorescence detection. Pronethalol is used as the internal standard. The procedure, which involves extraction into an organic solvent, evaporation, and clean-up by micro-scale back extraction from hexane into an aqueous phase, is specific and sensitive. The detection limit is less than 6 microgram/L (2.3 X 10(-8) mol/L). Within-day and between-day coefficients of variation are 1.8 and 4.4%, respectively. Commonly used drugs, including procainamide, N-acetylprocainamide, and quinidine, do not interfere.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1979 by the American Association for Clinical Chemistry.